Pregnancy Test Kits.. How they works

To support the ongoing pregnancy every Pregnant Women produces a hormone called hCG (Human Chorionic Gonadotrophin). The pregnancy test kits work by detecting this hCG in the urine of the pregnant women. Usually hCG appears in the urine of pregnant women after 20-24 days from the day of her last menstrual period. The level of hCG rapidly increases (almost doubles every 72hrs) till the third month of pregnancy and then maintains a steady state.
Now coming to the question how pregnancy test kits detect hCG.
The pregnancy test kits will have a chromatographic paper enclosed inside a plastic case and you can see the chromatographic paper from the upper side. The Chromatographic paper will be impregnated with hCG and anti hCG (a substance against hCG) at the point marked as ‘C’ and only with anti hCG at the point marked as ‘T’. C stands for “Control” and T stands for “Test”.

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There will a sample well where urine drops has to be poured and the urine will blot through out the chromatographic paper
Now the principle is
hCG + anti hCG + water = color
Let us take an example that a woman is not pregnant and she wants to check whether she is pregnant. She will put her urine in the sample well and the urine will blot through the chromatographic paper and it will cross both the “control” as well as the “Test” bands.
Now apply the principle here
Since the women is not pregnant her urine will not have hCG
At the Control area which is already impregnates with hCG +anti hCG a color band will appear because of the water from the urine but at the test area which is having only anti hCG no color will appear
so What happens at Control Band is?
hCG +anti hCG +water (from urine) = color.
This is basically to ensure that the pregnancy test kit is working.
and What happens at Test Band is?
Anti hCG + water (from urine) = no color
Since the woman is not pregnant her urine will not have hCG. There will be only one pink colored band appearing at the control area and the test band will not be colored.
Let us assume that the woman is pregnant and her urine will have hCG now.
Applying the principle
At Control Band
hCG (already impregnated) + hCG (from urine) + anti hCG + water (from urine) = color
At Test Band
hCG (from urine) + anti hCG + water (from urine) = color
Now two colored bands can be seen at both Control and Test areas.
This means the test is positive. Congrats you are pregnant and it's time for you to consult a Doctor.

Pregnancy and Bleeding


There are many different reasons that a woman may have vaginal bleeding during pregnancy. Some women can continue to have light periods or spotting during pregnancy, especially during the first few months. A pregnancy test would probably help to ease your mind. A visit to your practitioner may also be in order, either for early pregnancy care or to find out the reasons for your symptoms. Here is a comprehensive list of the many possible causes.

Early Pregnancy and Implantation Bleeding

Are you experiencing first trimester bleeding? It's estimated that 25% of all women have bleeding in early pregnancy. One possible cause of this bleeding is implantation bleeding.

What is Implantation Bleeding?

Implantation bleeding is lighter than menstrual bleeding, and consists of pink or brown colored blood. Implantation bleeding occurs when the trophoblast, or tissue that surrounds the egg, attaches to the endometrium and slowly eats its way into the lining. As it does so, it eats through the mother's blood vessels, forming blood lakes within itself. When these blood lakes form near the surface of the trophoblast, they often cause implantation bleeding.

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Remember, the difference between period and implantation bleeding is the amount; implantation bleeding is considerably lighter than menstrual bleeding. Menses and implantation bleeding should be different enough so that you can tell. Here are some frequently asked questions about spotting:

When does implantation bleeding occur?

Usually 5-12 days after ovulation, so just around the time that you would be getting your period. Bleeding during ovulation is something different.

What does implantation bleeding look like?

Implantation bleeding signs are a light pink or brown colored spotting.

How long does implantation bleeding last?

The duration varies for each woman.

Miscarriage

Bleeding while pregnant doesn't mean that miscarriage is certain, but it can occur. About half of the women who bleed do not have miscarriages. Miscarriage can occur at any time during the first half of pregnancy. Most occur during the first 12 weeks. Miscarriage occurs in about 15 to 20 percent of pregnancies. If you think you have passed fetal tissue, take it to the doctor's office so it can be examined.

Most miscarriages cannot be prevented. They are often the body's way of dealing with a pregnancy that was not normal. There is no proof that exercise or sex causes miscarriage.

Ectopic Pregnancy

Another problem that may cause pain and bleeding in early pregnancy is ectopic pregnancy. If pregnancy occurs in a fallopian tube, it may burst. Ectopic pregnancies are much less common than miscarriages. They occur in about one in 60 pregnancies.

Molar Pregnancy

A rare cause of early bleeding is molar pregnancy. It is also called gestational trophoblastic disease (GTD) or simply a "mole." It is the growth of abnormal tissue instead of an embryo.

Late Pregnancy

The causes of bleeding in the second half of pregnancy differ from those in early pregnancy. Common conditions that cause minor bleeding include an inflamed cervix or growths on the cervix.

Placental Abruption

The placenta may detach from the uterine wall before or during labor. This may cause vaginal bleeding. Only 1 percent of pregnant women have experienceplacental abruption. It usually occurs during the last 12 weeks of pregnancy. Stomach pain often occurs, even if there is no obvious bleeding.

Placenta Previa

When the placenta lies low in the uterus, it may partly or completely cover the cervix. This is called placenta previa. It may cause vaginal bleeding. Placenta previa is serious and requires prompt care.

Labor

Late in pregnancy, vaginal bleeding may be a sign of labor. A plug that covers the opening of the uterus during pregnancy is passed just before or at the start of labor. A small amount of mucus and blood is passed from the cervix. This is called "bloody show." It is common. It is not a problem if it happens within a few weeks of your due date.

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Preconception Tips


Preconception Prep for Moms

Ready to board that cute little pas senger on the mother ship? Here are some preconception steps you can take to make sure that ship is in shape.

Get a preconception checkup.

You don't have to choose a prenatal practi­tioner yet but it would be a good idea to see your regular gynecolo­gist for a thorough physical examination. An exam will pick up any medical problems that need to be corrected beforehand or that will need to be mon­itored during pregnancy. Plus, your doctor will be able to steer you away from medications that are to be avoided in pregnancy (or preconception), make sure your immunizations are up to date, and talk to you about your weight, your diet, your drinking and other lifestyle habits, and similar preconception issues.

Start looking for a prenatal practi­tioner.

It's easier to start looking for an obstetrician or midwife now, when the pregnancy meter's not already running, than when that first prenatal checkup is hanging over your head. If you're going to stick with your regular ob-gyn, then you've got a head start. Otherwise, ask around, scout around, and take your time in picking the practitioner who's right for you. Then schedule an inter­view and a pre-pregnancy examination.

Smile for the dentist.

A visit to the den­tist before you get pregnant is almost as important as a visit to the doctor. That's because your future pregnancy can affect your mouth—and your mouth can possibly affect your future preg­nancy. Pregnancy hormones can actu­ally aggravate gum and tooth problems, making a mess of a mouth that's not well taken care of to begin with. What's more, research shows that gum disease may be associated with some pregnancy complications. So before you get busy making a baby, get busy getting your mouth into shape. Be sure, too, to have any necessary work, including X-rays, fillings, and dental surgery, completed now so that it won't have to be done during pregnancy.

Check your family tree.

Get the health history on both sides of the family tree (yours and your spouse's). It's especially important to find out if there's a history of any medical issues and genetic or chromosomal disorders such as Down syndrome, Tay-Sachs disease, sickle cell anemia, thalassemia, hemophilia, cystic fibrosis, muscular dystrophy, or fragile X syndrome.

Take a look at your pregnancy history.

If you've had a previous pregnancy with any complications or one that ended with a premature delivery or late pregnancy loss, or if you've had multiple mis­carriages, talk to your practitioner about any measures that can be taken to head off a repeat.

Seek genetic screening, if necessary.

Also ask your practitioner about being tested for any genetic disease com­mon to your ethnic background: cystic fibrosis if either of you is Caucasian; Tay-Sachs disease if either of you is of Jewish-European (Ashkenazi), French Canadian, or Louisiana Cajun descent; sickle cell trait if you are of African descent; one of the thalassemias if you are of Greek, Italian, Southeast Asian, or Filipino origin.

Previous obstetrical difficulties (such as two or more miscarriages, a stillbirth, a long period of infertility, or a child with a birth defect) or being married to a cousin or other blood relative are also reasons to seek genetic counseling.

Ectopic Pregnancy


What is an ectopic pregnancy?

It's a pregnancy that develops outside the womb, usually in one of the fallopian tubes. That is why it is also known as a tubal pregnancy. It happens in about two of every 100 pregnancies in India.

As the pregnancy grows, it causes pain and bleeding and, if not recognized, the tube can rupture, causing internal bleeding. This is a medical emergency and can be fatal. The pregnancy itself never survives -- it can't be moved to the womb and has to be removed.

When is it likely to happen?

An ectopic is most commonly found between the fourth and tenth week of pregnancy -- usually from weeks five to seven.

Why does it happen?

The fertilised egg normally spends four to five days travelling down the tube from the ovary to the womb where it implants and begins to develop. The most common reason for an ectopic pregnancy is when the fallopian tube has been damaged, and this causes a blockage or narrowing which prevents the egg from reaching its destination. Instead, it implants in the wall of the tube.

In a few cases, the egg implants in an ovary, in the cervix, directly in the abdomen, or even in an earlier c-section scar. In rare cases, a woman may have a normal pregnancy in her uterus and an ectopic pregnancy at the same time. This is called a heterotopic pregnancy and it's more likely to happen if you've had fertility treatments, such as in-vitro fertilisation.

Who is at risk?

An ectopic pregnancy can happen to any woman, but there are circumstances, which make it more likely. These might include:

Þ If you've had pelvic inflammatory disease (which is most often caused by the sexually transmitted infection chlamydiaor or gonorrhoea) as this can cause damage and scarring to the fallopian tubes. Some experts believe that up to half of all ectopic pregnancies are related to the chlamydia infection. Experts also believe that if chlamydia has affected your fallopian tubes then your risk of an ectopic pregnancy is much increased.

Þ If you have tubal endometriosis. You may be more at risk because this increases the risk of scarring.

Þ If you've had any abdominal surgery, including an appendix removal or a caesarian section.

Þ If you have a contraceptive coil fitted. While this will prevent a pregnancy in the womb, it's less effective at preventing one in the tube.

Þ If you are taking the contraceptive mini-pill. This has been associated with a slightly higher rate of ectopic pregnancy.

Þ If you've had a previous ectopic pregnancy.

Þ If you are over 35.

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What are the symptoms?

Þ One-sided pain in the lower abdomen that is severe and persistent is the most common symptom. Many women describe it as an intense stabbing pain. Any woman who experiences this and who could possibly be pregnant should see a doctor.

Þ Collapse, preceded by feeling faint, dizziness, diarrhoea, vomiting and/or pain.

Þ Vaginal bleeding. You might not know that you're pregnant and mistake this for a period, but the blood is usually different from a normal period - often dark and watery.

Þ Shoulder-tip pain. This can happen if there is internal bleeding which irritates other internal body organs, such as the diaphragm.

Þ Pain in the lower back

Þ Pain when having a wee or opening your bowels.

What should I do?

If you have any of these symptoms, go to hospital right away. You're likely to be referred for an ultrasound examination and a sensitive pregnancy test (unless the tube has ruptured, in which case you'll go straight to surgery).

The scan may be done using an intravaginal probe, as the pregnancy may not show up using an abdominal scan. You might also have a blood hormone test if the scan isn't conclusive.

How is it treated?

If an ectopic pregnancy is suspected you will probably be taken to theatre for a laparoscopic examination (where a narrow viewing instrument is put into your abdomen through a tiny cut) to inspect your tubes. If an ectopic is discovered, the surgeon can remove this using the laparoscope to cut the tube and remove the pregnancy, leaving the tube intact.

If the tube has ruptured, sometimes abdominal surgery is needed rather than laparoscopic surgery (although not always) to remove the pregnancy and tubal damage. In some cases, a blood transfusion may be needed to replace lost blood.

In some hospitals the drug methotrexate, which terminates the pregnancy, can be used instead of surgery. This treatment is most effective in very early pregnancy and it can be used where there is no bleeding and the tube has not ruptured. The pregnancy is lost and reabsorbed by the mother, who will then experience bleeding for a couple of weeks. Methotrexate may also be used if the ectopic is picked up very early on and the levels of the pregnancy hormone HCG are still fairly low.

However, do let your doctor know if you are breastfeeding an older child or if you have certain health conditions. In such cases, your doctor may not prescribe the medicine and would look at other options, which may include surgery.

Note: If your blood is Rh-negative, you'll need a shot of Rh immunoglobulin after being treated for an ectopic pregnancy (unless the baby's father is also Rh negative).

Will it affect my fertility?

The answer to this is yes, possibly.
If your fallopian tubes are undamaged after an ectopic pregnancy, then your chances of conceiving again remain the same. If one of the tubes ruptured or was badly damaged, your chances of conceiving again are reduced. Up to ten per cent of women may become infertile after an ectopic.

Some 65 per cent of women will conceive again within 18 months of an ectopic, but if both your fallopian tubes were damaged or ruptured, you may need to think about IVF treatment.

What are the chances of having another ectopic?

There's about a 10 per cent risk of having another one. However, the risk is difficult to generalise about because of the differences in individual circumstances and the extent of the damage that takes place. That means that your overall chances of having a normal pregnancy next time around are still high.

You should arrange for a follow up appointment and ask for clear advice about your own future pregnancies from a consultant obstetrician.

There is little you can do to prevent an ectopic pregnancy from happening in the future, although if your ectopic has been caused by a current chlamydia infection you can have a course of antibiotics to clear it up and reduce further damage to your tubes.

When you do become pregnant again, see your doctor as soon as you can as you would be referred to an early pregnancy unit for a scan to check that your pregnancy is developing in the right place.

How long should I wait before trying for another?

Normally women who've had a laparoscopy are advised to wait three to four months before trying to conceive again. If you have had abdominal surgery, it's best to wait for six months to allow scarring to heal.


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